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Several classes of medications, collectively referred to as antihypertensive drugs, are currently available for treating hypertension. If the blood pressure goal is not met, a change in treatment should be made as therapeutic inertia is a clear impediment to blood pressure control.
Comorbidity also plays a role in determining target blood pressure, with lower BP targets applying to patients with end-organ damage or proteinuria. Often multiple medications are needed to be combined to achieve the goal blood pressure. Guidelines on the choice of first line agent and how to best to step up treatment with multiple agents for various subgroups of patients have changed over time and differ between countries.
In the UK low dose thiazide-based diuretic were previously thought the best first line agent, but latest guidelines emphasise calcium channel blockers CCB in preference for patients over the age of 55 years or if of African or Caribbean family origin, with angiotensin converting enzyme inhibitors ACE-I used first line for younger patients. If a fourth agent is needed then additional diuretics of spironolactone or a higher-dose of a thiazide-like diuretics.
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Additional agents that may be considered are alpha blockers or beta blockers. Beta-blockers may be also be considered in younger people, particularly those with an intolerance or contraindication to ACE-I and angiotensin II receptor antagonists, or women of child-bearing potential, or people with evidence of increased sympathetic drive. This reduces the volume of the blood, decreasing blood return to the heart and thus cardiac output and, by other mechanisms, is believed to lower peripheral vascular resistance.
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Hydrochlorothiazide is a calcium-sparing diuretic, meaning it can help the body get rid of excess water while still keeping calcium. Hydrochlorothiazide is frequently used for the treatment of hypertension, congestive heart failure, symptomatic edema, diabetes insipidus, renal tubular acidosis, and the prevention of kidney stones.
Lisinopril is a drug of the angiotensin-converting enzyme ACE inhibitor class that is primarily used in treatment of hypertension, congestive heart failure, and heart attacks and also in preventing renal and retinal complications of diabetes. Its indications, contraindications and side effects are as those for all ACE inhibitors. Claim your free Amlodipine Benazepril discount Click the "Get free coupon" button to receive your free Amlodipine Benazepril discount Print, email or text message your coupon Present your coupon the next time you fill your prescription.
Amlodipine Benazepril Information: What How Precautions Side Effects Overdose Additional Info This medicine is a calcium channel blocker, angiotensin II receptor blocker, and thiazide diuretic combination used to treat high blood pressure. It may also be used to treat other conditions as determined by your doctor. Follow the directions for using this medicine provided by your doctor. Ask your doctor, nurse, or pharmacist any questions that you may have about this information. This medicine may be taken on an empty stomach or with food.
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To prevent this from disturbing your sleep, try to take your dose before 6 pm. Take this medicine regularly to receive the most benefit from it. Taking this medicine at the same time each day will help you to remember. Do not miss any doses. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
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DO NOT take 2 doses at once. This medicine may cause birth defects or fetal or newborn death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. If you are planning to become pregnant, talk with your doctor about other treatment options.
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Some medicines or medical conditions may interact with this medicine. Inform your doctor of any other medical conditions, including dehydration, low blood volume, high or low blood electrolyte levels eg, sodium, magnesium, potassium, calcium , allergies, pregnancy or if you are able to become pregnant, or breast-feeding. Tell your doctor if you have a history of gallbladder or liver problems; kidney problems eg, renal artery stenosis ; asthma; gout or high blood levels of uric acid; lupus; parathyroid gland problems; low blood pressure; blood vessel problems; heart problems eg, heart failure, angina, narrowing of heart blood vessels ; high blood cholesterol or lipid levels; diabetes; swelling or fluid retention; stroke; heart attack; kidney transplant; or angioedema eg, swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; hoarseness , including angioedema caused by treatment with another angiotensin II receptor blocker eg, losartan or an ACE inhibitor eg, ramipril.
Tell your doctor if you drink alcohol, if you are on dialysis, if you will be having surgery, if you have recently had a certain type of nerve surgery sympathectomy , if you are on a low-salt sodium diet, or if you have never taken another medicine for high blood pressure. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine. SIDE EFFECTS that may occur while taking this medicine include dizziness, headache, indigestion, mild back pain, mild sore throat or discomfort when swallowing, muscle spasms, nausea, stuffy nose, tiredness, or upset stomach.
If they continue or are bothersome, check with your doctor. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away. Your risk may be increased if you are allergic to sulfonamide medicines eg, sulfamethoxazole or to penicillin antibiotics eg, amoxicillin.